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|Section2= |Section3= }} The cortistatins are a group of steroidal alkaloids first isolated in 2006 from the marine sponge ''Corticium simplex''. The cortistatins were first discovered in a search for naturally-occurring compounds that inhibit proliferation of human umbilical vein endothelial cells (HUVECs), with cortistatin A being the most potent compound in the class. The Shair group at Harvard along with collaborators have shown that cortistatin A is a highly potent and selective inhibitor of CDK8 and CDK19, the kinases that associate with Mediator complex. Out of 386 kinases evaluated, cortistatin A only inhibited CDK8 and CDK19, revealing that it is among the most selective kinase inhibitor Di-dehydrocortistatin A suppresses viral replication in cells infected with HIV via binding to the Tat protein. Cortistatin A was synthesized by the Shair, Myers, Baran and Nicolaou labs. == Chemical structures == File:Cortistatin A structure.svg|Cortistatin A File:Cortistatin B.svg|Cortistatin B File:Cortistatin C structure.svg|Cortistatin C File:Cortistatin D.svg|Cortistatin D File:Cortistatin E.svg|Cortistatin E File:Cortistatin F.svg|Cortistatin F File:Cortistatin G.svg|Cortistatin G File:Cortistatin H.svg|Cortistatin H File:Cortistatin J structure.svg|Cortistatin J File:Cortistatin K.svg|Cortistatin K File:Cortistatin L.svg|Cortistatin L 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「cortistatins」の詳細全文を読む スポンサード リンク
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