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Cyclobenzaprine, brand names Flexeril among others, is a muscle relaxer medication used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions.〔 It is the best-studied drug for this application.〔 It has also been used off-label for fibromyalgia treatment. A new sublingual formulation of cyclobenzaprine is under development for the chronic management of fibromyalgia syndrome.〔(【引用サイトリンク】title=Tonix Pharmaceuticals Holding Corp. (TNXP) )〕 == Medical use == After sustaining an injury, muscle spasms may occur to stabilize the affected body part and prevent further damage. They also generate pain. Cyclobenzaprine is FDA-approved to treat such muscle spasms associated with acute, painful musculoskeletal conditions. It decreases pain in the first two weeks, peaking in the first few days, but has no proven benefit after two weeks.〔 Since no benefit is proven beyond that, therapy should not be continued long-term. It is not useful for spasticity due to neurologic conditions such as cerebral palsy.〔 Cyclobenzaprine has also shown effectiveness in the treatment of fibromyalgia symptoms, with a report of 4.8 patients needing treatment for each (1) patient reporting pain reduction (but no change in fatigue or tender points). Some experts believe that cyclobenzaprine should be avoided in elderly patients, because it can cause confusion, delirium, and cognitive impairment.〔Canadian Agency for Drugs and Technologies in Health; 2015 Feb 23. Long-term Use of Cyclobenzaprine for Pain: A Review of the Clinical Effectiveness. PMID 25763449〕〔Potentially inappropriate medications for the elderly according to the revised Beers criteria. 2012. (Duke Clinical Research Institute website. ) http://www.americangeriatrics.org/files/documents/beers/2012AGSBeersCriteriaCitations.pdf〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「cyclobenzaprine」の詳細全文を読む スポンサード リンク
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