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daclatasvir
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Daclatasvir (USAN〔(Statement on a Nonproprietary Name Adopted by the USAN Council )〕) (formerly BMS-790052, trade name Daklinza,LediHep First generic version of DACLATASVIR awaits approval in india and to be marketed by Zydus Cadila is a drug for the treatment of hepatitis C (HCV). It is was developed by Bristol-Myers Squibb and was approved in Europe on 22st August 2014. Daklinza gained its FDA approval on July 24, 2015 in the United States; it is approved for Hepatitis C genotype 3 infections. 〔http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm455888.htm〕
Daclatasvir inhibits the HCV nonstructural protein NS5A. Recent research suggests that it targets two steps of the viral replication process, enabling rapid decline of HCV RNA.〔(Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life ). Guedj, J et al. Proceedings of the National Academy of Sciences. February 19, 2013.〕
Daclatasvir has been tested in combination regimens with pegylated interferon and ribavirin,〔(AASLD: Daclatasvir with Pegylated Interferon/Ribavirin Produces High Rates of HCV Suppression ). Highleyman, L. HIVandHepatitis.com. 6 December 2011.〕 as well as with other direct-acting antiviral agents including asunaprevir〔(Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1 ). Lok, A et al. ''New England Journal of Medicine''. 366(3):216-224. January 19, 2012.〕〔(【引用サイトリンク】 Bristol-Myers' Daclatasvir, Asunaprevir Cured 77%: Study )〕〔(AASLD: Daclatasvir plus Asunaprevir Rapidly Suppresses HCV in Prior Null Responders ). Highleyman, L. HIVandHepatitis.com. 8 November 2011.〕〔(High rate of response to BMS HCV drugs in harder-to-treat patients – but interferon-free prospects differ by sub-genotype ). Alcorn, K. Aidsmap.com. 12 November 2012.〕 and sofosbuvir.〔(AASLD 2012: Sofosbuvir + Daclatasvir Dual Regimen Cures Most Patients with HCV Genotypes 1, 2, or 3 ). Highleyman, L. HIVandHepatitis.com. 15 November 2012.〕
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
==References==
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