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| Section2 = }} Deguelin is a derivative of rotenone. Both are compounds classified as rotenoids of the flavonoid family and are naturally occurring insecticides. They can be produced by extraction from several plant species belonging to three genera of the Fabaceae or Legume family, ''Lonchocarpus'', ''Derris'', or ''Tephrosia''. Cubé resin, the root extract from Cubé (''Lonchocarpus utilis'') and from Barbasco (''Lonchocarpus urucu''), is used as a commercial insecticide and piscicide (fish poison). The major active ingredients are rotenone and deguelin. Although "organic" (produced by nature) cubé resin is no longer considered environmentally safe. ==Pharmacokinetics== * Mean residence time (MRT) = 6.98 h * Terminal half-life (t1/2(gamma)) = 9.26 h * Area under the curve (AUC) = 57.3 ng h/ml * Total clearance (Cl) = 4.37 l/h per kg * Apparent volume of distribution (V) = 3.421 l/kg * Volume of distribution at steady-state (Vss) = 30.46 l/kg * Tissue distributions after i.v. (intravenous) administration: heart > fat > mammary gland > colon > liver > kidney > brain > lung. * Tissue distributions after i.g. (intragastric) administration: perirenal fat > heart > mammary gland > colon > kidney > liver > lung > brain > skin. * Elimination: Within 5 days of i.g. administration, about 58.1% of the ()deguelin was eliminated via the feces and 14.4% via the urine. Approximately 1.7% of unchanged deguelin was found in the feces, and 0.4% in the urine. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「deguelin」の詳細全文を読む スポンサード リンク
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