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〕 | elimination_half-life = 9–11 hours〔 pH-dependent: 8–31 hours | duration_of_action = dosing: 3–7 hours〔 dosing: 12 hours〔〔〔 | excretion = Renal (45%); urinary pH-dependent | CAS_number_Ref = | CAS_number = 51-64-9 | ATC_prefix = N06 | ATC_suffix = BA02 | ATC_supplemental = | PubChem = 5826 | IUPHAR_ligand = 2147 | DrugBank_Ref = | DrugBank = DB01576 | ChemSpiderID_Ref = | ChemSpiderID = 5621 | UNII_Ref = | UNII = TZ47U051FI | KEGG_Ref = | KEGG = D03740 | ChEBI_Ref = | ChEBI = 4469 | ChEMBL_Ref = | ChEMBL = 612 | synonyms = | chemical_formula = | C=9 | H=13 | Ag= | As= | Au= | B= | Bi= | Br= | Cl= | Co= | F= | Fe= | Gd= | I= | K= | Mn= | N=1 | Na= | O= | P= | Pt= | S= | Sb= | Se= | Sr= | Tc= | Zn= | charge= | molecular_weight = 135.20622 | smiles = C()(Cc1ccccc1)N | StdInChI_Ref = | StdInChI = InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1 | StdInChI_comment = | StdInChIKey_Ref = | StdInChIKey = KWTSXDURSIMDCE-QMMMGPOBSA-N | density = 0.913 | melting_point = | melting_notes = | boiling_point = 201.5 | boiling_notes = | solubility = 20 }} Dextroamphetamine (USAN) is a potent central nervous system (CNS) stimulant and amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.〔 Dextroamphetamine is also widely used by military air forces as a 'go-pill' during fatigue-inducing mission profiles such as night-time bombing missions. Preparations containing dextroamphetamine were also used in World War II as a treatment against fatigue. The amphetamine molecule exists as two enantiomers (i.e., two different molecules that are mirror images of one another), levoamphetamine and dextroamphetamine. Dextroamphetamine is the more active dextrorotatory, or "right-handed", enantiomer of the amphetamine molecule. Pharmaceutical dextroamphetamine sulfate is available as both a brand name and generic drug in a variety of dosage forms. Dextroamphetamine is sometimes prescribed as the inactive prodrug lisdexamfetamine dimesylate, which is converted into dextroamphetamine after absorption. Dextroamphetamine, like other amphetamines, elicits its stimulating effects via three distinct actions: first, it inhibits or reverses the transporter proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) via trace amine-associated receptor 1 (TAAR1); second, it releases these neurotransmitters from synaptic vesicles via vesicular monoamine transporter 2; and third, it reduces the enzymatic breakdown of cytosolic dopamine, norepinephrine, serotonin and related trace amines via inhibition of monoamine oxidase, particularly at high concentrations of amphetamine and monoamine transmitters. It also shares many chemical and pharmacological properties with human trace amines, particularly phenethylamine and , the latter being an isomer of amphetamine produced within the human body. ==Uses== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「dextroamphetamine」の詳細全文を読む スポンサード リンク
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