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Dextropropoxyphene〔US Patent 2728779 - Esters of Substituted Aminobutanes〕 is an analgesic in the opioid category, patented in 1955〔Thieme Chemistry (Hrsg.): RÖMPP Online – Version 3.32. Georg Thieme Verlag KG, Stuttgart, 30. April 2013.〕 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias.〔(Physicians Say Good Riddance to 'Worst Drug in History' ) By Allison Gandey. February 2, 2011〕 Its onset of analgesia (pain relief) is said to be 20–30 minutes and peak effects are seen about 1.5–2 hours after oral administration.〔 Dextropropoxyphene is sometimes combined with paracetamol or aspirin. Trade names include Darvocet-N and Di-Gesic,〔(【引用サイトリンク】title=Consumer Medicine Information: Digesic )〕 Darvon with APAP (for dextropropoxyphene and paracetamol) and Darvon with ASA (for dextropropoxyphene and aspirin).〔Nursing Drug Handbook, Springhouse, page 306〕 The British approved name (i.e. the generic name of the active ingredient) of the paracetamol/dextropropoxyphene preparation is "''co-proxamol''" (sold under a variety of brand names); however, it has been withdrawn since 2007, and is no longer available to new patients, with exceptions.〔BNF Edition 57, BNF.org〕 The paracetamol combination(s) are known as Capadex or Di-Gesic in Australia, Lentogesic in South Africa, and Di-Antalvic in France (unlike co-proxamol, which is an approved name, these are all brand names). Dextropropoxyphene is known under several synonyms, including: * Alpha-d-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate * (methyl-1,2-diphenylbutan-2-yl ) propanoate * (+)-1,2-Diphenyl-2-propionoxy- 3-methyl-4-di-methylaminobutane * Desoxypropiophen ==Uses== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「dextropropoxyphene」の詳細全文を読む スポンサード リンク
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