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dezocine : ウィキペディア英語版
dezocine

Dezocine (DalganTM WY16225) is an opioid analgesic. First synthesized in 1970,〔(【引用サイトリンク】url=http://worldwide.espacenet.com/publicationDetails/biblio?CC=DE&NR=2159324&KC=&FT=E&locale=en_EP )〕 it acts at mu-, delta-, and kappa-opioid receptors. Dezocine acts as a mixed agonist/antagonist of opioid receptors. It is related to other benzomorphans such as pentazocine, with a similar profile of effects that include analgesic action and euphoria. Unlike many other benzomorphans however, it is a silent antagonist of the κ-opioid receptor, and in accordance, does not produce side effects such as dysphoria or hallucinations at any dose.
== History ==
Dezocine was patented by American Home Products Corp. in 1978. Clinical trials ran from 1979-1985, before its approval by the U.S. Food and Drug Administration (FDA) in 1986. As of 2011, dezocine's usage is discontinued in the United States.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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