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diaminopyrimidine : ウィキペディア英語版
diaminopyrimidine
Diaminopyrimidines are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.


They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim 〔http://aac.asm.org/cgi/content/full/45/12/3293 "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001〕 and the antibiotics Iclaprim and trimethoprim).
Some have been patented as anti-cancer drugs.〔http://www.wipo.int/pctdb/en/wo.jsp?IA=GB1998000111&DISPLAY=DESC〕
==See also==

* 2,4-Diaminopyrimidine
* 4,5-Diaminopyrimidine

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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