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diazoxide : ウィキペディア英語版
diazoxide

Diazoxide (INN; brand name Proglycem〔(Diazoxide ), drugs.com〕) is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels, preventing calcium flux across the sarcolemma and activation of the contractile apparatus.
In the United States, this agent is typically given in hospital.
==Uses==
Diazoxide is used as a vasodilator in the treatment of acute hypertension or malignant hypertension.
Diazoxide also inhibits the secretion of insulin from the pancreas, thus it is used to counter hypoglycemia in disease states such as insulinoma (a tumor producing insulin) or congenital hyperinsulinism.
Diazoxide acts as a positive allosteric modulator of the AMPA and kainate receptors, suggesting potential application as a cognitive enhancer.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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