|
|Section2= |Section3= |Section4= |Section5= }} Dimethylacetamide (DMA) is the organic compound with the formula CH3C(O)N(CH3)2. This colorless, water-miscible, high boiling liquid is commonly used as a polar solvent in organic synthesis. DMA is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons. ==Synthesis, reactions, applications== DMA is prepared by the reaction of dimethylamine with acetic anhydride and esters of acetic acid. Dehydration of the salt of dimethylamine and acetic acid also furnishes this compound: : CH3CO2H·HN(CH3)2 → H2O + CH3CON(CH3)2 The chemical reactions of dimethylacetamide are typical of ''N'',''N''-disubstituted amides. It will hydrolyze in the presence of acids: : CH3CON(CH3)2 + H2O + HCl → CH3COOH + (CH3)2NH2+Cl− It is however resistant to bases. For this reason DMA is useful solvent for reactions involving strong bases such as sodium hydroxide. Dimethylacetamide is commonly used as a solvent for fibers (e.g., polyacrylonitrile, spandex) or in the adhesive industry.〔 It is also employed in the production of pharmaceuticals and plasticizers as a reaction medium. Dimethylacetamide is also used as an excipient in drugs, e.g. in Vumon (teniposide), Busulfex (busulfan) or Amsidine (amsacrine). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「dimethylacetamide」の詳細全文を読む スポンサード リンク
|