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eoxin
Eoxins are a family of proinflammatory eicosanoids (signaling compounds that regulate inflammatory and immune responses) that are produced in human eosinophils (a class of white blood cells) and mast cells through the metabolism of arachidonic acid, an omega-6 (ω-6) fatty acid, by the arachidonate 15-lipoxygenase-1 enzyme.〔 The eoxins represent 14,15-leukotriene analogs and are synthesized in a similar manner to the standard leukotrienes.〔〔 Eoxins contribute to inflammation in airway allergies and certain types of cancers, particularly Hodgkin's lymphoma (a cancer originating from white blood cells), prostate cancer, and colon carcinoma.〔
==History and name==
The eoxins are 14,15-analogs of LTA4, LTC4, LTD4, and LTE4. Because the leukotrienes and 14,15-leukotrienes have very similar names, the 14,15-leukotrienes were renamed "eoxins" to avoid the confusion that might arise from referring to both group as "leukotrienes".〔 The eoxins derive their name from eosinophils, the cell type where they were originally discovered in abundance.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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