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Eperisone (formulated as the eperisone hydrochloride salt) is an antispasmodic drug. Eperisone acts by relaxing both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. The drug inhibits the vicious circle of myotonia by decreasing pain, ischaemia, and hypertonia in skeletal muscles, thus alleviating stiffness and spasticity, and facilitating muscle movement Eperisone also improves dizziness and tinnitus associated with cerebrovascular disorders or cervical spondylosis. Eperisone has a relatively low incidence of sedation when compared with other antispasmodic drugs; this simplifies the clinical application of the drug and makes it an attractive choice for patients who require antispasmodic therapy without a reduction in alertness. Eperisone also facilitates voluntary movement of the upper and lower extremities without reducing muscle power; it is therefore useful during the initial stage of rehabilitation and as a supporting drug during subsequent rehabilitative therapy. ==Indications== *Spastic paralysis in conditions such as cerebrovascular disease〔http://www.curehunter.com/public/keywordSummaryC030848--4--ethyl-2-methyl-3-piperidino-propiophenone.do〕 *Spastic spinal paralysis *Cervical spondylosis *Postoperative sequelae (including from cerebrospinal tumour)〔http://squarepharma.com.bd/SPL_PI_PDF/myonil226.pdf〕 *Sequelae to trauma (e.g. spinal trauma or head injury)〔 *Amyotrophic lateral sclerosis *Cerebral palsy *Spinocerebellar degeneration *Spinal vascular diseases and other encephalomyelopathies *Cervical syndrome, periarthritis of the shoulder, and lumbago.〔http://www.europeanreview.org/articolo.php?id=502〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「eperisone」の詳細全文を読む スポンサード リンク
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