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fibrosis
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This can be a reactive, benign, or pathological state. In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. Physiologically, fibrosis acts to deposit connective tissue, which can obliterate the architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing.〔(Glossary of dermatopathological terms. DermNet NZ )〕
==Physiology==
Fibrosis is similar to the process of scarring, in that both involve stimulated cells laying down connective tissue, including collagen and glycosaminoglycans. Immune cells called macrophages, as well as any damaged tissue between surfaces called interstitium, release TGF beta. There are numerous reasons for this, including inflammation of the nearby tissue, or a generalised inflammatory state, with increased circulating mediators. TGF beta stimulates the proliferation and activation of fibroblasts, which deposit connective tissue.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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