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| floctafenine ： ウィキペディア英語版 |
floctafenine
Floctafenine is a non-steroidal anti-inflammatory drug (NSAID).
==Synthesis==
The scheme involves first the conversion of ortho-trifluoromethyl aniline (1) to a quinolol. The compound is thus condensed
with EMME (Ethoxy Methylene Malonic Diethyl Ester) and cyclized thermally (2). That intermediate is then saponified; the
resulting acid is decarboxylated and finally converted to the 4-chloroquinoline (3) by reaction with phosphorus oxychloride. The displacement of chlorine with methyl anthranilate (4) then affords the coupled intermediate (5). An ester interchange
of that product with glycerol leads to the glyceryl ester. There is thus obtained the NSAID floctafenine.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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