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flunitrazepam
Flunitrazepam , also known as Rohypnol among others,〔http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3380 NCBI〕 is an intermediate acting benzodiazepine used as an hypnotic, sedative, anticonvulsant, anxiolytic, and skeletal muscle relaxant drug. In general, the prescription of flunitrazepam as a hypnotic is intended to be for short-term treatment of chronic or severe insomniacs not responsive to other hypnotics, especially in inpatients. It is considered to be one of the most effective benzodiazepine hypnotics on a dose basis. Just as with other hypnotics, flunitrazepam should be strictly used only on a short-term basis or in those with chronic insomnia on an occasional basis. It is also known and produced from common precursors to 1,4-benzophenones, in 1963.〔US Patent US 3203990 2-amino-2'-halo-5-nitro benzophenones〕 Flunitrazepam has been referred to as a date rape drug because of its high potency and ability to cause strong amnesia. However, Robertson's study (in the 1990s) indicated that flunitrazepam was used in only around 1% of reported date rapes and 0.33% according to urine lab tests done (before 2001) by El Sohly.
Flunitrazepam is classed as a nitro-benzodiazepine. It is the fluorinated N-methyl derivative of nitrazepam. Other nitro-benzodiazepines include nitrazepam (the parent compound), nimetazepam (methylamino derivative) and clonazepam (the chlorinated derivative).
==History==
Flunitrazepam was developed by a team led by Leo Sternbach at Hoffmann La-Roche and produced from common precursors to 1,4-benzophenones, in 1963.〔US Patent US 3203990 2-amino-2'-halo-5-nitro benzophenones〕 Flunitrazepam has been referred to as a date rape drug because of its high potency and ability to cause strong amnesia. However, Robertson's study (in the 1990s) indicated that Flunitrazepam was used in only around 1% of reported date rapes and 0.33% according to urine lab tests done (before 2001) by El Sohly.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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