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fosmidomycin
Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus ''Streptomyces''. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the ''E. coli'' enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the ''Francisella'' enzyme at 99 nM.〔Jawaid, S., Seidle, H., Zhou W, Abdirahman, H., Abadeer, M, Hix, JH, van Hoek, ML and RD Couch. Kinetic Characterization and Phosphoregulation of the Francisella tularensis 1-Deoxy-D-Xylulose 5-Phosphoate Reductoisomerase (MEP Synthase), PLOS One, 4(12): e8288. 〕
==Use in malaria==
The discovery of the non-mevalonate pathway in malaria parasites has indicated the use of fosmidomycin and other such inhibitors as antimalarial drugs. Indeed, fosmidomycin has been tested in combination treatment with clindamycin for treatment of malaria with favorable results. It has been shown that an increase in copy number of the target enzyme (DXP reductoisomerase) correlates with ''in vitro'' fosmidomycin resistance in the lethal malaria parasite, ''Plasmodium falciparum''.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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