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galeterone : ウィキペディア英語版
galeterone

Galeterone (TOK-001 or VN/124-1) is a novel steroidal antiandrogen under development by Tokai Pharmaceuticals for the treatment of prostate cancer. It possesses a unique dual mechanism of action, acting as both an androgen receptor antagonist and an inhibitor of CYP17A1, an enzyme required for the biosynthesis of the androgens. It shows selectivity for 17,20-lyase over 17-hydroxylase. As of the second half of 2014, galeterone is in phase III clinical trials for castration-resistant prostate cancer.〔(【引用サイトリンク】 author = Yahoo! Finance )
==See also==

* Abiraterone acetate
* Enzalutamide
* Apalutamide
* Orteronel
* VT-464
* ODM-201
* EPI-001

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「galeterone」の詳細全文を読む



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