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|Section2= |Section3= |Section4= |Section5= |Section6= |Section7= |Section8= }} Gliotoxin is a sulfur-containing mycotoxin produced by several species of fungi, especially those of marine origin. It is the most prominent member of the epipolythiopiperazines, a large class of natural products featuring a diketopiperazine with di- or polysulfide linkage. These highly bioactive compounds have been the subject of numerous studies aimed at new therapeutics.〔Jiang, C.-S.; Muller, W. E. G.; Schroder, H. C.; Guo, Y.-W., "Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms", Chem. Rev. 2012, 112, 2179-2207. 〕 Gliotoxin was originally isolated from ''Gliocladium fimbriatum'', and was named accordingly. It is an epipolythiodioxopiperazine metabolite. ==Occurrence== The compound is produced by human pathogens such as ''Aspergillus fumigatus'', and also by species of ''Trichoderma'', and ''Penicillium''. Gliotoxin has also been reported from yeasts of the genus ''Candida'',〔Larsen, B,Shah, D, 1991 "Candida isolates of yeast produce a gliotoxin-like substance" Mycopathologia 116:203-208, 1991.〕 but results from other studies have cast doubt on the production of this metabolite by ''Candida'' fungi. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「gliotoxin」の詳細全文を読む スポンサード リンク
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