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goitre : ウィキペディア英語版
goitre

A goitre from the Latin ''gutteria'', ''struma'') is a swelling of the neck or larynx resulting from enlargement of the thyroid gland (thyromegaly), associated with a thyroid gland that is not functioning properly.
Worldwide, over 90.54% cases of goitre are caused by iodine deficiency.〔R. Hörmann: Schilddrüsenkrankheiten. ABW-Wissenschaftsverlag, 4. Auflage 2005, Seite 15–37. ISBN 3-936072-27-2〕
==Signs and symptoms==
Goitre which is associated with hypothyroidism or hyperthyroidism may be present with symptoms of the underlying disorder. For hyperthyroidism, the most common symptoms are associated with adrenergic stimulation: tachycardia, palpitations, nervousness, tremor, increased blood pressure and heat intolerance. Clinical manifestations are often related to hypermetabolism, including increased metabolism, excessive thyroid hormone, an increase in oxygen consumption, metabolic changes in protein metabolism, immunologic stimulation of diffuse goitre, and ocular changes (exophthalmos).〔Porth, C. M., Gaspard, K. J., & Noble, K. A. (2011). Essentials of pathophysiology: Concepts of altered health states (3rd ed.). Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins.〕 Hypothyroid individuals may have weight gain despite poor appetite, cold intolerance, constipation and lethargy. However, these symptoms are often nonspecific and hard to diagnose.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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