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gossypol : ウィキペディア英語版
gossypol

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Gossypol is a natural phenol derived from the cotton plant (genus ''Gossypium''). Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It is a yellow pigment.
Among other things, it has been tested as a male oral contraceptive in China. In addition to its contraceptive properties, gossypol has also long been known to possess antimalarial properties. Other researchers are investigating the anticancer properties of gossypol.
==Biological properties==
It has proapoptotic properties, probably due to the regulation of the Bax and Bcl2 genes. It also reversibly inhibits calcineurin and binds to calmodulin. It inhibits replication of the HIV-1 virus. It is an effective protein kinase C inhibitor.〔(Gossypol (Gossipol) ). Bioscreening.net (last updated 2008-07-09). Retrieved on 2012-06-09.〕
It also causes low potassium levels, and thus causes temporary paralysis.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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