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guanfacine
Guanfacine (brand name Estulic, Tenex and the extended release Intuniv) is a sympatholytic drug used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former.〔.〕 Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone.〔.〕
Guanfacine is currently approved and marketed in the United States as Intuniv〔(【引用サイトリンク】website=Drugs.com )〕 and has been filed and is under investigation by the European Medicines Agency〔(【引用サイトリンク】website=PharmiWeb.com )〕 for the treatment of ADHD in children and adolescents aged 6–18 years.
==Medical uses==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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