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| hypoprothrombinemia ： ウィキペディア英語版 |
hypoprothrombinemia
Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.
==Causes==
Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication. For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).
It may also be a rare adverse effect to Rocephin.〔(Rocephin proscribing information ). Accessed October 24, 2013.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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