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immunophilins : ウィキペディア英語版 | immunophilins
In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that between the cis and trans positions. Immunophilins are targeted by immunosuppressive drugs such as Sirolimus (earlier rapamycin), cyclosporine, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the ''cis-trans'' isomerization of peptide bonds, particularly X-Pro peptide bonds. This isomerase activity can be inhibited by immunosuppressive drugs. ==See also==
* FKBP12 * FKBP52 * FKBP5 = FKBP51
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「immunophilins」の詳細全文を読む
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