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kavalactone
Kavalactones are a class of lactone compounds found in the kava shrub. Kavalactones have a wide variety of effects including amnestic, analgesic, anticonvulsant, anxiolytic, nootropic, and sedative/hypnotic activity caused by numerous interactions with the central nervous system via several mechanisms.
==Enzyme inhibition==
Kava extract has been shown to potently inhibit a wide range of hepatic enzymes, suggesting a very high potential for interactions with many pharmaceuticals and herbal medications.〔(【引用サイトリンク】author=James M. Mathews, Amy S. Etheridge and Sherry R. Black )〕 For this reason, kava should never be consumed without the permission of a primary care physician, psychiatrist, and/or any other doctor who is prescribing medication for a patient. It is also recommended that potential users discuss their kava use with a pharmacist. If undergoing anesthesia, it is recommended to note any use of kava well in advance of any surgery. Patients may be instructed to temporarily discontinue use of kava for a set period of time before and after the surgery.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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