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A Koilocyte is a squamous epithelial cell that has undergone a number of structural changes, which occur as a result of infection of the cell by human papillomavirus. Koilocytosis or koilocytic atypia or koilocytotic atypia are terms used in histology and cytology to describe the presence of koilocytes in a specimen. Koilocytes may have the following cellular changes: *Nuclear enlargement (two to three times normal size) *Irregularity of the nuclear membrane contour *A darker than normal staining pattern in the nucleus, known as Hyperchromasia *A clear area around the nucleus, known as a perinuclear halo. Collectively, these types of changes are called a cytopathic effect; various types of cytopathic effect can be seen in many different cell types infected by many different types of virus. When examining cytologic specimens, mild koilocytosis is characteristic of ASC-US (atypical squamous cells - undetermined significance). A more undifferentiated koilocyte, possessing a more hyperchromatic and enlarged nucleus, and a higher degree of cytoplasmic clearing with a discernible peripheral rim favor an interpretation of LSIL (low-grade squamous intraepithelial lesion).〔〔 Koilocytes may be found in potentially precancerous cervical, oral and anal lesions.〔 ==Interpretation== These changes occur in the presence of human papillomavirus and occasionally can lead to cervical intraepithelial neoplasia, and if left untreated some may eventually progress to malignant cancer. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「koilocyte」の詳細全文を読む スポンサード リンク
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