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Labetalol (INN)(trade names Normodyne and Trandate) is a mixed alpha/beta adrenergic antagonist that is used to treat high blood pressure. It can be given intravenously in severe hypertensive situations, or by mouth for long term hypertension management.〔 Its dose and use is limited by its main side effect—postural hypotension, where there is a substantial drop in blood pressure when standing up.〔 Labetalol's dual alpha- and beta- blockade has different physiological effects in short and long term situations. In short term, acute situations, labetalol decreases blood pressure by decreasing systemic vascular resistance with little effect on stroke volume, heart rate and cardiac output.〔 During long term use, labetalol can reduce heart rate during exercise while maintaining cardiac output by an increase in stroke volume.〔 ==Medical uses== Labetalol is effective in the management of hypertensive emergencies, postoperative hypertension, pheochromocytoma-associated hypertension, and rebound hypertension from beta blocker withdrawal. It has a particular indication in the treatment of pregnancy-induced hypertension which is commonly associated with pre-eclampsia. It is also used as an alternative in the treatment of severe hypertension.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「labetalol」の詳細全文を読む スポンサード リンク
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