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lacidipine : ウィキペディア英語版
lacidipine

Lacidipine (tradenames Lacipil (GSK) or Motens (Boehringer Ingelheim)) is a calcium channel blocker. It is available as tablets containing 2 or 4 mg.
==Synthesis==

The synthesis starts with the Wittig reaction of phthalaldehyde (1) with the ylide from triphenylphosphonium salt (2). The ''trans'' stereochemistry of the product (3) follows from the fact that the rxn is not carried out under salt-free conditions; selectivity for monoalkylation is probably due to steric hindrance from the newly introduced adjacent side chain to the adjacent formyl group. reaction of tat intermediate with ethyl acetoacetate and ammonia gives the dihydropyridine lacidipine (5).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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