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lamin
Nuclear lamins, also known as Class V intermediate filaments, are fibrous proteins providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with membrane-associated proteins to form the nuclear lamina on the interior of the nuclear envelope. They are involved in the disassembling and reforming of the nuclear envelope during mitosis, as well as the positioning of nuclear pores.
==A- and B-types==
In animal cells, there are A- and B-type lamins, which differ in their length and isoelectric point (pI). Human cells have three differentially regulated genes.
* B-type lamins are present in every cell. B type lamins, B1 and B2, are expressed from the LMNB1 and LMNB2 genes on 5q23 and 19q13, respectively.
* A-type lamins are expressed only following gastrulation. Lamin A and C are the most common A-type lamins and are splice variants of the LMNA gene found at 1q21.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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