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A lentigo () (plural lentigines, ) is a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread. This means the hyperplasia of melanocytes is restricted to the cell layer directly above the basement membrane of the epidermis where melanocytes normally reside. This is in contrast to the "nests" of multi-layer melanocytes found in moles (melanocytic nevi). Because of this characteristic feature, the adjective "lentiginous" is used to describe other skin lesions that similarly proliferate linearly within the basal cell layer.〔''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 1101. ISBN 0-375-72026-X.〕〔''Robbins and Cotran Pathologic Basis of Disease'' Elsevier. 2005. Page 1232. ISBN 0-8089-2302-1 .〕 Lentigines are distinguished from freckles (ephelis) based on the proliferation of melanocytes. Freckles have a relatively normal number of melanocytes but an increased ''amount'' of melanin. A lentigo has an increased ''number'' of melanocytes. Freckles will increase in number and darkness with sunlight exposure, whereas lentigines will stay stable in their color regardless of sunlight exposure.〔 Conditions characterized by lentigines include: : * Lentigo simplex : * Solar lentigo (Liver spots) : * PUVA lentigines : * Ink spot lentigo : * LEOPARD syndrome : * Mucosal lentigines : * Multiple lentigines syndrome : * Moynahan syndrome : * Generalized lentiginosis : * Centrofacial lentiginosis : * Carney complex : * Inherited patterned lentiginosis in black persons : * Partial unilateral lentiginosis : * Peutz-Jeghers syndrome : * Acral lentiginous melanoma == See also == * Skin lesion * Skin disease * List of skin diseases 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「lentigo」の詳細全文を読む スポンサード リンク
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