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leonurine
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Leonurine is an alkaloid that has been isolated from ''Leonotis leonurus'' (Lion's tail), ''Leonotis nepetifolia'', ''Leonotis artemisia'', ''Leonurus cardiaca'' (Motherwort), as well as other plants of family Lamiaceae. Leonurine is easily extracted into water, as well as from the essential oil of ''Leonurus sibiricus''.
==Chemical synthesis==
Leonurine can be synthesized starting from eudesmic acid. Reaction with sulfuric acid produces syringic acid. Protection with ethyl chloroformate followed by reaction with with thionyl chloride SOCl2 and then tetrahydrofuran yields 4-carboethoxysyringic acid 4-chloro-1-butyl ester. The chloride is then converted to an amino group via a Gabriel synthesis with potassium pthalimide) followed by hydrazinolysis (Ing–Manske procedure). The final step is reaction of the amine with ''S''-methylisothiourea hemisulfate salt.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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