|
|Section2= |Section3= }} Levopropoxyphene is an antitussive. It is an optical isomer of dextropropoxyphene. The racemic mixture is called propoxyphene. Only the dextro-isomer (dextropropoxyphene) has an analgesic effect; the levo-isomer appears to exert only an antitussive effect. It was formerly marketed in the U.S. by Eli Lilly under the tradename Novrad (a reversal of Darvon) as an antitussive.〔Reference.MD: (Propoxyphene napsylate )〕 ==Synthesis== #Mannich reaction of propiophenone with formaldehyde and dimethylamine affords the corresponding aminoketone. #Reaction of the ketone with benzylmagnesium bromide gives the amino alcohol. It is of note that this intermediate fails to show analgesic activity in animal assays. #Esterification of the alcohol by means of propionic anhydride affords the propionate. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「levopropoxyphene」の詳細全文を読む スポンサード リンク
|