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Lipedema or lipoedema is a chronic disorder of adipose tissue and lymphatic dysfunction generally affecting the legs, which causes the legs and sometimes the arms to accumulate distinct patterns of fatty tissue. It is distinguishable by six characteristics: # it can be inherited; # it occurs almost exclusively in women; # it can occur in women of all sizes, from the seriously underweight to the morbidly obese; # it involves the excess deposit and expansion of fat cells in an unusual and particular pattern – bilateral, symmetrical and usually from the waist to a distinct line just above the ankles; # unlike normal fat, lipedematous fat generally cannot be lost through diet and exercise; # the adipose tissue may present as painful, or, there may be pain when pressure is applied to the lipedematous areas; # a pathognomonic indicator of lipedema is that the feet are spared. Lipedema usually is triggered at puberty, but can trigger or worsen during or after pregnancy, at peri-menopause, and following gynecological surgery, i.e., surgery of the uterus, ovaries, or fallopian tubes or any surgery with general anesthesia. Lipedema can also be triggered by an extremely stressful situation such as a death in the family or a divorce because cortisol levels increase, causing an inflammation cascade, almost always misdiagnosed as simple weight gain. If lipedema is diagnosed early, which currently is very rare, it is possible to prevent a significant expansion of lipedematous fat cells and to alert patients to their heightened risk factors so they can take appropriate action. It is commonly misdiagnosed.〔 Estimates of the incidence of lipedema vary widely, and range as high as 11% of the post-pubertal female population, with estimates of 17 million women in the US, and 370 million women worldwide affected. ==Causes== The cause is unknown. There are likely genetically inherited risk factors as it is more likely to occur in the first and second degree relatives of affected individuals. It appears to be related to estrogen and progesterone hormonal influences as it occurs exclusively post puberty and largely in females. There is a strong inflammation component; some patients self-report an improvement of symptoms by moving to anti-inflammatory diets and/or eliminating foods that exacerbate inflammation. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「lipedema」の詳細全文を読む スポンサード リンク
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