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Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders.〔(Familial multiple lipomatosis )〕 In 1993, a genetic defect within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C. This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.〔http://www.genome.jp/dbget-bin/www_bget?omim+151900 Lipomatosis, Familial Multiple Lipomatosis, FML〕 Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction.〔(Familial multiple lipomatosis )〕 Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease),Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis,〔https://www.biomedcentral.com/1471-2253/14/70 Multiple Epidural Steroid Injections and Epidural Lipomatosis〕 and familial angiolipomatosis. ==See also== * Pelvic lipomatosis * Virchow's metamorphosis — lipomatosis in the heart and salivary glands. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「lipomatosis」の詳細全文を読む スポンサード リンク
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