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A lipopeptide is a molecule consisting of a lipid connected to a peptide. Bacteria express these molecules. They are bound by TLR 1, and other Toll-like receptors. Certain lipopeptides are used as antibiotics.〔(US Patent 6911525 - Lipopeptides as antibacterial agents )〕〔(Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections ), Judith N. Steenbergen *, Jeff Alder, Grace M. Thorne and Francis P. Tally , Journal of Antimicrobial Chemotherapy 2005 55(3):283-288; 〕 Certain lipopeptides could have strong anifungtal and hemolytic activities.〔Maget-Dana, R., & Peypoux, F. (1994). Iturins, a special class of pore-forming lipopeptides: biological and physicochemical properties. Toxicology, 87(1-3), 151–74〕 It has been demonstrated that their activity is generally linked to interactions with the plasma membrane 〔Nasir, M. N., Besson, F., & Deleu, M. (2013). Interactions des antibiotiques ituriniques avec la membrane plasmique. Apport des systèmes biomimétiques des membranes. Biotechnology, Agronomy and Society and Environment, 17(3), 505–516.〕 and sterol components of plasma membrane could play a major role and can be their privileged partner of interaction.〔Nasir, M. N., & Besson, F. (2012). Interactions of the antifungal mycosubtilin with ergosterol-containing interfacial monolayers. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818(5), 1302–1308〕〔Nasir, M. N., & Besson, F. F. (2011). Specific Interactions of Mycosubtilin with Cholesterol-Containing Artificial Membranes. Langmuir : The ACS Journal of Surfaces and Colloids, 27(17), 10785–10792.〕 ==Examples== *Surfactin *Daptomycin *Echinocandins (e.g., caspofungin) *iturin A *mycosubtilin *Bacillomycins 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「lipopeptide」の詳細全文を読む スポンサード リンク
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