|
Mepacrine (INN; also called quinacrine in the United States and Atabrine (trade name) is a drug with several medical applications. It is related to mefloquine. ==Medical uses== The main uses of mepacrine are as an antiprotozoal, antirheumatic and an intrapleural sclerosing agent.〔(Drugs.com: Quinacrine. ) Retrieved on August 24, 2009.〕 Antiprotozoal use include targeting giardiasis, where mepacrine is indicated as a primary agent for patients with metronidazole-resistant giardiasis and patients who should not receive or can not tolerate metronidazole. Giardiasis that is very resistant may even require a combination of mepacrine and metronidazole.〔 Mepacrine is also used "off-label" for the treatment of systemic lupus erythematosus, indicated in the treatment of discoid and subcutaneous lupus erythematosus, particularly in patients unable to take chloroquine derivatives.〔 As an intrapleural sclerosing agent, it is used as pneumothorax prophylaxis in patients at high risk of recurrence, e.g., cystic fibrosis patients.〔 Mepacrine is not the drug of choice because side effects are common, including toxic psychosis, and may cause permanent damage. See mefloquine for more information. In addition to medical applications, mepacrine is an effective in vitro research tool for the epifluorescent visualization of cells, especially platelets. Mepacrine is a green fluorescent dye taken up by most cells. Platelets store mepacrine in dense granules. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「mepacrine」の詳細全文を読む スポンサード リンク
|