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mertansine
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Mertansine refers to the thiol-containing maytansinoid DM1, which for therapeutic purposes is attached to a monoclonal antibody through reaction of the thiol group with a linker structure to create an antibody-drug conjugate (ADC).
Experimental ADCs with this design include lorvotuzumab mertansine.
==Mechanism of action==
Mertansine is a tubulin inhibitor, meaning that it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site).〔National Cancer Institute: (Definition of Maytansine )〕
The monoclonal antibody binds specifically to a structure (usually a protein) occurring in a tumour, thus directing mertansine into this tumour. This concept is called targeted therapy.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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