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metamizole
Metamizole (INN), or dipyrone (BAN, USAN), is an ampyrone sulfonate analgesic (pain reliever), antispasmodic (spasm reliever) and antipyretic (fever reducer) similar to paracetamol in that it has minimal anti-inflammatory effects and which is most commonly given orally or parenterally (by injection) to prevent and treat pain related to surgery or for the treatment of acute pain.〔 It was first introduced into clinical use in Germany in 1922 under the brandname "Novalgin" and for many years it was available over-the-counter in most countries, until its toxicities became apparent, although in some countries it is available over-the-counter, its use is usually restricted in developed countries, due to its potential for causing toxic reactions.〔
Metamizole is marketed under various trade names.〔
Despite its potential haematologic (blood-related) toxicity (that is potential for causing blood dyscrasias) it produces no clinically relevant effects in the way of kidney toxicity, cardiovascular toxicity and GI toxicity when compared to non-steroidal anti-inflammatory drugs (NSAIDs).〔 Unlike paracetamol and similarly to the NSAIDs it can trigger bronchospasm or anaphylaxis, especially in those with asthma.
==Medical uses==
It is primarily used for perioperative pain, although the clinical trial data to support this use is limited at best.〔 It is also used for acute injury, colic, cancer pain, other acute/chronic forms of pain and high fever unresponsive to other agents.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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