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|Section2= |Section7= |Section8= }} Mezerein is a toxic diterpene ester found in the sap of ''Daphne mezereum'' and related plants. Plants of the genus ''Euphorbiaceae'' and ''Thymelaeaceae'' possess a wide variety of different phorbol esters, which share the capacity of mimicking diacylglycerol (DAG) and thus activating different isoforms of protein kinase C. Mezerein was first isolated in 1975. It has antileukemic properties in mice, but it is also defined as a weak promoter of skin cancers in the same species. All parts of the plants contain an acrid and irritant sap that contains mezerein, thought to be the principal poison. The sap is especially prevalent in the bark and berries. Mezerein is highly liposoluble and can cause vomiting, diarrhea and burning of the mouth. When a large dose is taken, there can be shivering, dilation of the pupils, damage to the oral passages and the intestine and even death. It can also irritate the skin, resulting in redness by slight damage of the veins. Because of causing this redness, the sap used to be applied as rouge.〔 == History and alternative uses == Mezerein can be found in ''Daphne mezereum''.〔 This plant has been used to make dyes, treat rheumatism and indolent ulcers and as a cosmetic. In homeopathy, the plant is used to treat primarily skin disorders but is also prescribed to treat anxiety related to digestive disorders and congestion.〔(【引用サイトリンク】Mezereum Homeopathy Information )〕 Once the toxicity of the plant was discovered, these uses were abandoned. The toxicity also led to new uses. In extreme cases, the berries are used to commit suicide. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「mezerein」の詳細全文を読む スポンサード リンク
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