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Microalbuminuria is a term to describe a moderate increase in the level of urine albumin. It occurs when the kidney leaks small amounts of albumin into the urine, in other words, when there is an abnormally high permeability for albumin in the glomerulus of the kidney. The term 'microalbuminuria' is now discouraged by KDIGO (Kidney Disease Improving Global Outcomes) and has been replaced by 'moderately increased albuminuria'. ==Associations/Indications== * marker of vascular endothelial dysfunction * an important prognostic marker for kidney disease * * in diabetes mellitus * * in hypertension * * in post-streptococcal glomerulonephritis * increasing microalbuminuria during the first 48 hours after admission to an intensive care unit predicts elevated risk for acute respiratory failure, multiple organ failure, and overall mortality * a risk factor for venous thromboembolism Microalbuminuria is an important adverse predictor of glycemic outcomes in pre-diabetes. Pre-diabetes individuals with increased microalbuminuria even in the so-called normal range is associated with increased progression to diabetes and decreased reversal to normoglycemia. Hence prediabetes individuals with microalbuminuria warrant more aggressive intervention to prevent diabetes in them.〔Dutta D, Choudhuri S, Mondal SA, Mukherjee S, Chowdhury S. Urine albumin creatinine rationpredicts prediabetes progression to diabetes and reversal to normoglycemia: Role of associatedinsulin resistance, inflammatory cytokines and low vitamin-D. J Diabetes 2014 Jul;6(4):316-22 PMID 24251376 http://www.ncbi.nlm.nih.gov/pubmed/24251376〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「microalbuminuria」の詳細全文を読む スポンサード リンク
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