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microcystin
Microcystins (or cyanoginosins) are a class of toxins produced by certain freshwater cyanobacteria; primarily Microcystis aeruginosa but also other Microcystis, as well as members of the Planktothrix, Anabaena, Oscillatoria and Nostoc genera. Over 50 different microcystins have been discovered so far, of which Microcystin-LR is the most common. Chemically they are cyclic heptapeptides produced through nonribosomal peptide synthases.
Microcyctins can be produced in large quantities during algal blooms and pose a major threat to drinking and irrigation water supplies, as well as the environment at large.〔(【引用サイトリンク】publisher=Oregon State University )〕
==Characteristics==
Microcystin-LR is the most toxic form of over 80 known toxic variants, and is also the most studied by chemists, pharmacologists, biologists, and ecologists. Microcystin-containing 'blooms' are a problem worldwide, including China, Brazil, Australia, South Africa,〔Fatoki, O.S., Muyima, N.Y.O. & Lujiza, N. 2001. Situation analysis of water quality in the Umtata River Catchment. Water SA, (27) Pp 467-474.〕〔Oberholster, P. 2008. Parliamentary Briefing Paper on Cyanobacteria in Water Resources of South Africa. Annexure “A” of CSIR Report No. CSIR/NRE/WR/IR/2008/0079/C. Pretoria. Council for Scientific and Industrial Research (CSIR).〕 the United States and much of Europe.
Microcystins contain several uncommon non-proteinogenic amino acids such as dehydroalanine derivatives and the uncommon β-amino acid ADDA. Microcystins covalently bond to and inhibit protein phosphatases PP1 and PP2A and can thus cause pansteatitis.〔http://www.pwrc.usgs.gov/health/rattner/rattner_blackwaternwr.cfm〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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