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mitragynine : ウィキペディア英語版
mitragynine

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Mitragynine, an indole alkaloid, is the most abundant active alkaloid in the plant ''Mitragyna speciosa'', commonly known as Kratom and "Biak-Biak".〔Raffa RB, Beckett JR, Brahmbhatt VN, et al. Orally active opioid compounds from a non-poppy source. J Med Chem. 2013;56(12):4840-8.〕
== Subjective perceptions ==
In spite of the fact that mitragynine has sometimes been touted and used as a “legal opioid,” few scientific studies have addressed the psychoactive properties of mitragynine. 〔Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol. 1988;23(1)115-119.〕〔Suwanlert S. A study of kratom eaters in Thailand. Bull Narc. 1975;27(3):21-27〕〔Jansen KL, Prast CJ. Psychoactive properties of mitragynine (kratom). J Psychoactive Drugs. 1988;20(4):455-457.〕〔Shellard EJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol. 1989;25(1):123-124.〕 Most of the available information is based on anecdotal reports and patient experiences. The general subjective effects of mitragynine have been summarized in various reviews and include improved mood and analgesia, with some subjects experiencing relaxation and others stimulation (paradoxical effects).〔Adkins JE, Boyer EW, McCurdy CR. Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. Curr Top Med Chem. 2011;11(9):1165-1175.〕

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