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Monocerin is a dihydroisocoumarin and a polyketide metabolite that originates from various fungal species. It has been shown to display antifungal, plant pathogenic, and insecticidal characteristics. Monocerin has been isolated from ''Dreschlera monoceras'', ''D. ravenelii'', ''Exserohilum turcicum'', and ''Fusarium larvarum''. == Biosynthesis == Polyketide synthases (PKSs) of fungi are Type I PKSs. Monocerin has been confirmed by biosynthesis studies to have heptaketide origins. Monocerin PKS produces an intermediate with initially a high degree of reductive modification but ends with a classical β-polyketide moiety. Dihydroisocoumarin is the first PKS-free intermediate which would be formed from the reduced heptaketide whose assembly pathway is shown in figure 1. Ketosynthase, ketoreductase, dehydrates, enol reductases and cyclisases are shown as domains of the Monocerin PKS and methyl transferase is considered to be a tailoring enzyme. # Formation of an enolate ion on the carbon three carbons away from sulfur allows aldol addition onto the carbonyl six carbons distant along the chain. This produces the secondary alcohol. Dehydration proceeds to give the alkene. Enolization then occurs to reach the stability of the aromatic ring. #The modified chain is transferred to the TE domain. This will allow lactonization and release from the enzyme.〔 # Hydroxylation occurs at ortho-position to two substituents. O-methylation occurs.〔 # O-methylation # Cylclic-ether formation 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「monocerin」の詳細全文を読む スポンサード リンク
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