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Montelukast (trade names Singulair, Montelo-10, and Monteflo and Lukotas in India, Lumona, Arokast in Bangladesh and Respicare in Pakistan) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.〔Lipkowitz, Myron A. and Navarra, Tova (2001) ''The Encyclopedia of Allergies'' (2nd ed.) Facts on File, New York, p. 178, ISBN 0-8160-4404-X〕〔("Asthma / Allergy " ). Mascothealth.com. Retrieved 9 April 2011.〕 Montelukast comes as a tablet, a chewable tablet, flash tablet and granules to take by mouth.〔 Montelukast is usually taken once a day with or without food.〔Montelukast article on Medline Plus http://www.nlm.nih.gov/medlineplus/druginfo/meds/a600014.html "Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth. Montelukast is usually taken once a day with or without food."〕 Montelukast is a CysLT1 antagonist; it blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific mechanism of action, it does not interact with other asthma medications such as theophylline. Another leukotriene receptor antagonist is zafirlukast (Accolate). Zileuton (Zyflo), an asthma drug, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway. The ''Mont'' in Montelukast stands for Montreal, the place where Merck developed the drug.〔http://www.merckfrosst.ca/mfcl/en/corporate/research/accomplishments/singulair.html〕 ==Medical uses== Montelukast is used for a number of conditions including asthma, exercise induced bronchospasm, allergic rhinitis, primary dysmenorrhoea and urticaria.〔(【引用サイトリンク】url=http://www.drugs.com/monograph/montelukast-sodium.html )〕 It is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids, if they alone do not bring the desired effect. It is also used to prevent allergic reactions and asthma flare-ups during the administration of intravenous immunoglobulin. Montelukast is administered as montelukast sodium, with 5.2mg of montelukast sodium being equivalent to 5mg of montelukast. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「montelukast」の詳細全文を読む スポンサード リンク
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