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Myelofibrosis, also known as osteomyelofibrosis, is a rare bone marrow cancer.〔(【引用サイトリンク】url=https://www.lls.org/content/nationalcontent/resourcecenter/freeeducationmaterials/mpd/pdf/idiopathicmyelofibrosis.pdf )〕 It is currently classified as a myeloproliferative neoplasm, in which the proliferation of an abnormal clone of hematopoietic stem cells in the bone marrow and other sites results in fibrosis, or the replacement of the marrow with scar tissue. The term ''myelofibrosis'' alone usually refers to primary myelofibrosis (PMF), also known as chronic idiopathic myelofibrosis (cIMF); the terms idiopathic and primary mean that in these cases the disease is of unknown or spontaneous origin. This is in contrast with myelofibrosis that develops secondary to polycythemia vera or essential thrombocythaemia. Myelofibrosis is a form of myeloid metaplasia, which refers to a change in cell type in the blood-forming tissue of the bone marrow, and often the two terms are used synonymously. The terms Agnogenic myeloid metaplasia and myelofibrosis with myeloid metaplasia (MMM) are also used to refer to myelofibrosis. ==Signs and symptoms== The primary sign of myelofibrosis is reactive bone marrow fibrosis,〔 but it is often accompanied by: *Abdominal fullness related to an enlarged spleen (splenomegaly). *Bone pain *Bruising and easy bleeding due to inadequate numbers of platelets *Cachexia (loss of appetite, weight loss, and fatigue) *Enlargement of both the liver and spleen *Fatigue *Gout and high uric acid levels *Increased susceptibility to infection, such as pneumonia *Pallor and shortness of breath due to anemia *In rarer cases, a raised red blood cell volume * Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「myelofibrosis」の詳細全文を読む スポンサード リンク
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