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naftifine : ウィキペディア英語版
naftifine

Naftifine (brand name Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).
Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.〔Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.〕〔Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at (www.thomsonhc.com/../BeginWith#secN10184 ), February 18, 2010.〕 The half-life is approximately 2–3 days.〔 The metabolites are excreted in the urine and feces.〔AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620§ion=10, February 18, 2010.〕
==References==



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