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nanodisc
A nanodisc is a synthetic model membrane system which assists in the study of membrane proteins. Nanodiscs are useful for membrane biology in the study of membrane proteins because they represent a more native environment than liposomes, detergent micelles or bicelles and allow the study of purified membrane proteins. Nanodiscs consist of a small portion of membrane that has been solubilized by the addition of two molecules of an amphipathic protein, dubbed the membrane scaffold protein (MSP). This protein wraps around the hydrophobic core of the lipids, effectively creating a soluble portion of membrane. When prepared properly, nanodiscs are uniform in size and allow a native local environment to be maintained within a larger ''in vitro'' study.
== Further reading ==
Some recent publications and reviews
Shih, A.Y., Freddolino, P.L., Arkhipov, A., Sligar, S.G., and Schulten, K. (2008) (Molecular Modeling of the Structural Properties and Formation of High-Density Lipoprotein Particles ) Current Topics in Membranes 60, 313-342. ISBN 978-0-12-373893-6
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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