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Naphazoline (in the hydrochloride form) is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops. It has the molecular formula C14H14N2.HCl and a molecular weight of 246.73 g/mol. ==Warnings and contraindications== A few warnings and contraindications that apply to all naphazoline-containing substances intended for medicinal use are: * Hypersensitivity to naphazoline * Patients taking MAO inhibitors can experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline HCl * Use in infants and children can result in central nervous system depression, leading to coma and marked reduction in body temperature * Should be used with caution in patients with severe cardiovascular disease including cardiac arrhythmia and in patients with diabetes, especially those with a tendency toward diabetic ketoacidosis * Drug interactions can occur with anaesthetics that sensitize the myocardium to sympathomimetics (e.g. cyclopropane or halothane cautiously) * Exercise caution when applying prior to use of phenylephrine. * Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion. A possible association with stroke has been suggested. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「naphazoline」の詳細全文を読む スポンサード リンク
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