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neoflavonoid : ウィキペディア英語版
neoflavonoid

Neoflavonoids are a class of polyphenolic compounds.〔(The neoflavanoids, a new class of natural products. Cellular and Molecular Life Sciences, Volume 22, Number 12 / december 1966 )〕 While flavonoids (in the narrow sense) have the 2-phenylchromen-4-one backbone, neoflavonoids have the 4-phenylchromen backbone with no hydroxyl group substitution at position 2.
==Types==

Neoflavonoids include 4-arylcoumarins (neoflavones), 4-arylchromanes, dalbergiones and dalbergiquinols.
* Neoflavones〔(Revised structure of neoflavone in Coutarea hexandra. Munekazu Iinuma, Toshiyuki Tanaka, Koji Hamada, Mizuo Mizuno, Fujio Asai, Gesa Reher and Ljubomir Kraus, Phytochemistry, Volume 26, Issue 11, 1987, Pages 3096-3097. )〕 are derived from the 4-phenylcoumarin (or 4-Aryl-coumarin) backbone (C15H12O2, molar mass : 224.25g/mol, exact mass : 224.083729).〔(Structures of 4-Aryl-coumarin (Neoflavone) Dimers Isolated from Pistacia chinensis BUNGE and Their Estrogen-like Activity. Satoshi NISHIMURA, Motohiko TAKI, Sachiko TAKAISHI, Yasuteru IIJIMA and Toshiyuki AKIYAMA, Chem. Pharm. Bull. 48(4) 505—508 (2000) )〕 The first neoflavone isolated from natural sources in 1951 was calophyllolide from ''Calophyllum inophyllum'' seeds.〔(Neoflavones. 1. Natural Distribution and Spectral and Biological Properties. M. M. Garazd, Ya. L. Garazd and V. P. Khilya, Chemistry of Natural Compounds, Volume 39, Number 1 / janvier 2003. )〕 It is also known to found in bark and timber of Sri Lankan endemic plant ''Mesua thwaitesii''.〔(Xanthones and 4-phenylcoumarins of ''Mesua thwaitesii'' from bark, timber and seeds. )〕
* Neoflavenes possess the 4-phenylchromen backbone (chemical formula : C15H10O2, exact mass : 222.0680792). Dalbergichromene, extracted from the stem-bark and heartwood of ''Dalbergia sissoo'', is an example of such compounds〔(Dalbergichromene : A new neoflavonoid from stem-bark and heartwood of Dalbergia sissoo. Mukerjee S. K., Saroja T. and SeshadriT. R., Tetrahedron, Volume 27, Issue 4, 1971, Pages 799-803 )〕

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