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Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now considered to be of no value for such purposes, and may be dangerous.〔Martindale, The Extra Pharmacopoeia, 30th ed, p1229〕 In alternate terminology, it is known as ''nicotinic acid diethylamide'', which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend. == Former and current medical use == Coramine was used by suspected serial killer John Bodkin Adams when treating patient Gertrude Hullett, whom he was suspected of murdering.〔Cullen, Pamela V., "A Stranger in Blood: The Case Files on Dr John Bodkin Adams", London, Elliott & Thompson, 2006, ISBN 1-904027-19-9〕 However, the toxicity of nikethamide is quite low ( rabbits 650 mg/Kg oral, LD50 rats 240 mg/Kg s.c.). Theodor Morell, Adolf Hitler's personal physician, would inject the German ruler with Coramine when Hitler was unduly sedated with barbiturates. In addition, Morell would use Coramine as part of an all-purpose "tonic" for Hitler. It is available as a short-acting over-the-counter drug in several South American and European countries, combined with glucose in form of lozenges. It is especially useful for mountain climbers to increase endurance at high altitudes. Contraindications include hypertension, cardiovascular pathologies and epilepsy.〔(Nikethamid ), III-3.3, Toxcenter〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「nikethamide」の詳細全文を読む スポンサード リンク
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