|
A nitrone is a functional group in organic chemistry, and is an N-oxide of an imine. The general structure is R1R2C=NR3+O− where R3 is not H. A nitrone is a 1,3-dipole, and is used in 1,3-dipolar cycloadditions. Other reactions of nitrones are known, including formal () cycloadditions to form 6-membered rings, as well as formal () cycloadditions to form 7-membered rings. == Generation of nitrones == Nitrones are generated most often either by the oxidation of hydroxylamines or condensation of monosubstituted hydroxylamines with carbonyl compounds (ketones or aldehydes). The most general reagent used for the oxidation of hydroxylamines is mercury(II) oxide. ''(2)'' Carbonyl condensation methods avoid issues of site selectivity associated with the oxidation of hydroxylamines with two sets of (alpha) hydrogens.''(3)'' A significant problem associated with many reactive nitrones is dimerization. This issue is alleviated experimentally by employing an excess of the nitrone or increasing the reaction temperature to exaggerate entropic factors. ''(4)'' 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「nitrone」の詳細全文を読む スポンサード リンク
|
